Journal: Genes
Article Title: Effects of Paraquat, Dextran Sulfate Sodium, and Irradiation on Behavioral and Cognitive Performance and the Gut Microbiome in A53T and A53T-L444P Mice.
doi: 10.3390/genes15030282
Figure Lengend Snippet: Figure 11. (A) In the open field, activity levels were higher in A53T than A54T-L444P mice (F(1,81) = 4.091, * p = 0.046). (B) In the rotorod test, there was a genotype × treatment interaction (F(1,81) = 7.773, p = 0.007). DSS impaired rotorod performance in A53T-L444P mice (F(1,45) = 9.228, *** p = 0.004), but not in A53T mice. (C) DSS reduced spontaneous alternation in A53T-L444P mice (F(1,45) = 7.191, * p = 0.01). (D) A53T-L44P mice showed reduced activity levels in the Y-maze (F(1,81) = 5.336, * p = 0.023). (E) During the baseline period in the fear conditioning test, activity levels were lower in A53T-L44P than A53T mice (F(1,81) = 7.565, ** p = 0.007). (F) In males, A53T-L44P mice showed lower activity levels than A53T mice during the baseline period (F(1,41) = 6.727, * p = 0.013). (G) In females, there was a treatment × genotype interaction (F(1,40) = 4.168, p = 0.048). DSS increased activity level in A53T-L44P females (F(1,22) = 5.119, * p = 0.034). (H) For the freezing levels during the ISI, there was a genotype × treatment × sex interaction (F(1,81) = 4.661, p = 0.034). (I) A53T-L44P mice had lower activity levels than A53T mice during the ISI (F(1,81) = 4.564, * p = 0.036). (J) When activity levels during the tones were analyzed, there was a genotype × treatment × sex interaction (F(1,81) = 8.199, p = 0.005). (K) A53T-L44P mice had lower activity levels than A53T mice during the contextual fear memory test (F(1,85) = 4.677, * p = 0.033). Circles: A53T; squares: A53T-L444P. Open symbols: H2O; filled symbols: DSS.
Article Snippet: Contextual and cued fear conditioning were assessed (Med Associates mouse fear conditioning system (PMED-VFC-NIR-M, Med Associates, St. Albans, Vermont and Med Associates VideoFreeze automated scoring system).
Techniques: Activity Assay
